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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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DEPOD - Substrate Search Result

Protein substrate


Entry_name Gene_namesUniProtIDDescription
WASLWASLWASL_HUMANNeural Wiskott-Aldrich syndrome protein;N-WASP;
SLC9A3R1SLC9A3R1, NHERF, NHERF1NHRF1_HUMANNa(+)/H(+) exchange regulatory cofactor NHE-RF1;NHERF-1;Ezrin-radixin-moesin-binding phosphoprotein 50;EBP50;Regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1;
AXIN1AXIN1, AXINAXIN1_HUMANAxin-1;Axis inhibition protein 1;hAxin;
LATLATLAT_HUMANLinker for activation of T-cells family member 1;36 kDa phospho-tyrosine adapter protein;pp36;p36-38;
PSTPIP1PSTPIP1, CD2BP1PPIP1_HUMANProline-serine-threonine phosphatase-interacting protein 1;PEST phosphatase-interacting protein 1;CD2-binding protein 1;H-PIP;
TBC1D4TBC1D4, AS160, KIAA0603TBCD4_HUMANTBC1 domain family member 4;Akt substrate of 160 kDa;AS160;
NFAT5NFAT5, KIAA0827, TONEBPNFAT5_HUMANNuclear factor of activated T-cells 5;NF-AT5;T-cell transcription factor NFAT5;Tonicity-responsive enhancer-binding protein;TonE-binding protein;TonEBP;
MYCMYC, BHLHE39MYC_HUMANMyc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64;
PDHA1PDHA1, PHE1AODPA_HUMANPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;1.2.4.1;PDHE1-A type I;
MAPTMAPT, MAPTL, MTBT1, TAUTAU_HUMANMicrotubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;
FCGR2AFCGR2A, CD32, FCG2, FCGR2A1, IGFR2FCG2A_HUMANLow affinity immunoglobulin gamma Fc region receptor II-a;IgG Fc receptor II-a;CDw32;Fc-gamma RII-a;Fc-gamma-RIIa;FcRII-a;CD32;
CDH1CDH1, CDHE, UVOCADH1_HUMANCadherin-1;CAM 120/80;Epithelial cadherin;E-cadherin;Uvomorulin;CD324;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;
EZREZR, VIL2EZRI_HUMANEzrin;Cytovillin;Villin-2;p81;
PLCG1PLCG1, PLC1PLCG1_HUMAN1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;3.1.4.11;PLC-148;Phosphoinositide phospholipase C-gamma-1;Phospholipase C-II;PLC-II;Phospholipase C-gamma-1;PLC-gamma-1;
NCLNCLNUCL_HUMANNucleolin;Protein C23;
RASA1RASA1, GAP, RASARASA1_HUMANRas GTPase-activating protein 1;GAP;GTPase-activating protein;RasGAP;Ras p21 protein activator;p120GAP;
CBLCBL, CBL2, RNF55CBL_HUMANE3 ubiquitin-protein ligase CBL;2.3.2.27;Casitas B-lineage lymphoma proto-oncogene;Proto-oncogene c-Cbl;RING finger protein 55;RING-type E3 ubiquitin transferase CBL;Signal transduction protein CBL;
MSNMSN MOES_HUMANMoesin;Membrane-organizing extension spike protein;
SHC1SHC1, SHC, SHCASHC1_HUMANSHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;Src homology 2 domain-containing-transforming protein C1;SH2 domain protein C1;
PDHA2PDHA2, PDHALODPAT_HUMANPyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial;1.2.4.1;PDHE1-A type II;
IRS1IRS1IRS1_HUMANInsulin receptor substrate 1;IRS-1;
BRCA1BRCA1, RNF53BRCA1_HUMANBreast cancer type 1 susceptibility protein;2.3.2.27;RING finger protein 53;RING-type E3 ubiquitin transferase BRCA1;
WASWAS, IMD2WASP_HUMANWiskott-Aldrich syndrome protein;WASp;
SIRPASIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRPSHPS1_HUMANTyrosine-protein phosphatase non-receptor type substrate 1;SHP substrate 1;SHPS-1;Brain Ig-like molecule with tyrosine-based activation motifs;Bit;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen;Signal-regulatory protein alpha-1;Sirp-alpha-1;Signal-regulatory protein alpha-2;Sirp-alpha-2;Signal-regulatory protein alpha-3;Sirp-alpha-3;p84;CD172a;
FKBP4FKBP4, FKBP52FKBP4_HUMANPeptidyl-prolyl cis-trans isomerase FKBP4;PPIase FKBP4;5.2.1.8;51 kDa FK506-binding protein;FKBP51;52 kDa FK506-binding protein;52 kDa FKBP;FKBP-52;59 kDa immunophilin;p59;FK506-binding protein 4;FKBP-4;FKBP59;HSP-binding immunophilin;HBI;Immunophilin FKBP52;Rotamase;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;
RELARELA, NFKB3TF65_HUMANTranscription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;
ARHGAP5ARHGAP5, RHOGAP5RHG05_HUMANRho GTPase-activating protein 5;Rho-type GTPase-activating protein 5;p190-B;
SKP2SKP2, FBXL1SKP2_HUMANS-phase kinase-associated protein 2;Cyclin-A/CDK2-associated protein p45;F-box protein Skp2;F-box/LRR-repeat protein 1;p45skp2;
NFATC2NFATC2, NFAT1, NFATPNFAC2_HUMANNuclear factor of activated T-cells, cytoplasmic 2;NF-ATc2;NFATc2;NFAT pre-existing subunit;NF-ATp;T-cell transcription factor NFAT1;
CTTNCTTN, EMS1SRC8_HUMANSrc substrate cortactin;Amplaxin;Oncogene EMS1;
POLD3POLD3, KIAA0039DPOD3_HUMANDNA polymerase delta subunit 3;DNA polymerase delta subunit C;DNA polymerase delta subunit p66;DNA polymerase delta subunit p68;
ARHGAP12ARHGAP12RHG12_HUMANRho GTPase-activating protein 12;Rho-type GTPase-activating protein 12;
CCAR2CCAR2, DBC1, KIAA1967CCAR2_HUMANCell cycle and apoptosis regulator protein 2;Cell division cycle and apoptosis regulator protein 2;DBIRD complex subunit KIAA1967;Deleted in breast cancer gene 1 protein;DBC-1;DBC.1;NET35;p30 DBC;
USP6NLUSP6NL, KIAA0019US6NL_HUMANUSP6 N-terminal-like protein;Related to the N-terminus of tre;RN-tre;
KIFAP3KIFAP3, KIF3AP, SMAPKIFA3_HUMANKinesin-associated protein 3;KAP-3;KAP3;Smg GDS-associated protein;
CEP250CEP250, CEP2, CNAP1CP250_HUMANCentrosome-associated protein CEP250;250 kDa centrosomal protein;Cep250;Centrosomal Nek2-associated protein 1;C-Nap1;Centrosomal protein 2;
CARD11CARD11, CARMA1 CAR11_HUMANCaspase recruitment domain-containing protein 11;CARD-containing MAGUK protein 1;Carma 1;
RACGAP1RACGAP1 , KIAA1478 RGAP1_HUMANRac GTPase-activating protein 1;Male germ cell RacGap;MgcRacGAP;Protein CYK4 homolog;CYK4;HsCYK-4;
ARHGAP35ARHGAP35 , GRF1 RHG35_HUMANRho GTPase-activating protein 35;Glucocorticoid receptor DNA-binding factor 1;Glucocorticoid receptor repression factor 1;GRF-1;Rho GAP p190A;p190-A;
PAG1PAG1, CBP, PAGPHAG1_HUMANPhosphoprotein associated with glycosphingolipid-enriched microdomains 1;Csk-binding protein;Transmembrane adapter protein PAG;Transmembrane phosphoprotein Cbp;
SPHK1SPHK1, SPHK, SPKSPHK1_HUMANSphingosine kinase 1;SK 1;SPK 1;2.7.1.91;
COL4A3BPCOL4A3BP, CERT, STARD11C43BP_HUMANCollagen type IV alpha-3-binding protein;Ceramide transfer protein;hCERT;Goodpasture antigen-binding protein;GPBP;START domain-containing protein 11;StARD11;StAR-related lipid transfer protein 11;
CD28CD28, CD28_HUMANT-cell-specific surface glycoprotein CD28;TP44;CD28;
EPS15EPS15, AF1P, EPS15_HUMANEpidermal growth factor receptor substrate 15;Protein Eps15;Protein AF-1p;
RESTREST, NRSF, XBR, REST_HUMANRE1-silencing transcription factor;Neural-restrictive silencer factor;X2 box repressor;
RUNX2RUNX2, AML3, CBFA1, OSF2, PEBP2A, RUNX2_HUMANRunt-related transcription factor 2;Acute myeloid leukemia 3 protein;Core-binding factor subunit alpha-1;CBF-alpha-1;Oncogene AML-3;Osteoblast-specific transcription factor 2;OSF-2;Polyomavirus enhancer-binding protein 2 alpha A subunit;PEA2-alpha A;PEBP2-alpha A;SL3-3 enhancer factor 1 alpha A subunit;SL3/AKV core-binding factor alpha A subunit;
LASP1LASP1, MLN50, LASP1_HUMANLIM and SH3 domain protein 1;LASP-1;Metastatic lymph node gene 50 protein;MLN 50;
PDCD1PDCD1, PD1, PDCD1_HUMANProgrammed cell death protein 1;Protein PD-1;hPD-1;CD279;

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