Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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PPIP5K1
Gene Name  | PPIP5K1 (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | PPIP5K1, HISPPD2A, IP6K, IPS1, KIAA0377, VIP1 | |
| Protein Name | PPIP5K1 |
|
| Alternative Name(s) |
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1;2.7.4.21;2.7.4.24;Diphosphoinositol pentakisphosphate kinase 1;Histidine acid phosphatase domain-containing protein 2A;IP6 kinase;Inositol pyrophosphate synthase 1;InsP6 and PP-IP5 kinase 1;VIP1 homolog;hsVIP1; | |
| EntrezGene ID | 9677 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q6PFW1 (protein sequence) | |
| Enzyme Class | EC 2.7.4.21 2.7.4.24 (BRENDA ) | |
| Molecular Weight | 159521 Dalton | |
| Protein Length | 1433 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000168781 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: histidine phosphatase (HP) --> Family: histidine acid phosphatase | Historic class: Histidine phosphatase (HP) | CATH ID: NA | SCOP Fold: HP | |
| Phosphatase activity | active | Catalytic signature motif: unknown | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm, cytosol Cell membrane Note=Relocalizes to the plasmamembrane upon activation of the PtdIns 3-kinase pathway | |||
| Function (UniProt annotation) | |||
| Bifunctional inositol kinase that acts in concert withthe IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize thediphosphate group-containing inositol pyrophosphatesdiphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 PP-InsP5 and(PP)2-InsP4, also respectively called InsP7 and InsP8, regulate avariety of cellular processes, including apoptosis, vesicletrafficking, cytoskeletal dynamics, exocytosis, insulin signalingand neutrophil activation Phosphorylates inositolhexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4Alternatively, phosphorylates at position 1 or 3 PP-InsP5,produced by IP6Ks from InsP6, to produce (PP)2-InsP4 Activatedwhen cells are exposed to hyperosmotic stress | |||
| Catalytic Activity (UniProt annotation) | |||
| ATP + 1D-myo-inositol hexakisphosphate = ADP +1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate)2,3,4,6-tetrakisphosphate ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate)2,3,4,6-tetrakisphosphate ATP + 1D-myo-inositol hexakisphosphate = ADP +1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate | |||
| Protein Sequence | |||
| MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCR FDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLP RYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVR KTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFD LLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRH GDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMY GHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCG LLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQ QDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLE RDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILL DLQRTHEDESVNKLHPLCYLRYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELN YMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRA LQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPN LQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHT DAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSL NSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQ KVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSL VQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000827 | F:inositol-1,3,4,5,6-pentakisphosphate kinase activity |
| GO:0000828 | F:inositol hexakisphosphate kinase activity |
| GO:0000829 | F:inositol heptakisphosphate kinase activity |
| GO:0000832 | F:inositol hexakisphosphate 5-kinase activity |
| GO:0005524 | F:ATP binding |
| GO:0005654 | C:nucleoplasm |
| GO:0005829 | C:cytosol |
| GO:0005886 | C:plasma membrane |
| GO:0006020 | P:inositol metabolic process |
| GO:0032958 | P:inositol phosphate biosynthetic process |
| GO:0033857 | F:diphosphoinositol-pentakisphosphate kinase activity |
| GO:0043647 | P:inositol phosphate metabolic process |
| GO:0052723 | F:inositol hexakisphosphate 1-kinase activity |
| GO:0052724 | F:inositol hexakisphosphate 3-kinase activity |
| GO:0102092 | F:5-diphosphoinositol pentakisphosphate 3-kinase activity |