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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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CHEBI:16851

Name 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateC11556
Download: mol | sdf
Synonyms01,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate);
1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;
2,3-bis(alkanoyloxy)propyl (1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonatooxy)cyclohexyl phosphate;
Pi(3,5)p2;
Pips;
Ptdins(3,5)p2;
Ptsins(3,5)p2;
Ptsins-3,5-p2;
Definition NA
Molecular Weight
(Exact mass)
NA
Molecular Formula C11H19O19P3R2
SMILES [H][C@@](COC([*])=O)(COP(O)(=O)O[C@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H]1O)OC([*])=O
InChI InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2-,3-,4+,5-,6-/m0/s1
InChI Key CIPFCGZLFXVXBG-CNWJWELYSA-N
Crosslinking annotations KEGG:C11556 | ChEBI:16851 | PubChem:13723 |

Pathway ID Pathway Name Pathway Description (KEGG)
map00562Inositol phosphate metabolismNA
map01100Metabolic pathwaysNA
map04070Phosphatidylinositol signaling systemNA
map04144EndocytosisEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.