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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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CHEBI:17526

Name 1-phosphatidyl-1D-myo-inositol 4-phosphateC01277
Download: mol | sdf
Synonyms01,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate);
1-phosphatidyl-1d-myo-inositol 4-monophosphate;
1-phosphatidyl-1d-myo-inositol 4-phosphate;
Na;
Phosphatidylinositol 4-phosphate;
Pi4p;
Pips;
Ptdins(4)p;
Ptdins-4-p;
Ptdins4p;
Definition A phosphatidylinositol 4-phosphate having 1D-myo-configuration.
Molecular Weight
(Exact mass)
NA
Molecular Formula C11H18O16P2R2
SMILES [H][C@@](COC([*])=O)(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1O)OC([*])=O
InChI InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
InChI Key VWFJDQUYCIWHTN-YFVJMOTDSA-N
Crosslinking annotations KEGG:C01277 | ChEBI:17526 | PubChem:4496 |

Pathway ID Pathway Name Pathway Description (KEGG)
map00562Inositol phosphate metabolismNA
map01100Metabolic pathwaysNA
map04070Phosphatidylinositol signaling systemNA
map05134LegionellosisLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated with Legionella species: Legionnaires' disease is the more severe form of the infection, which may involve pneumonia, and Pontiac fever is a milder respiratory illness.The pathogenesis of L. pneumophila is derived from its growth within lung macrophages. One of the L. pneumophila's type IV secretion systems, the Dot/Icm secretion system, is of critical importance for its ability to replicate and to cause disease. The Dot/Icm substrates modulate multiple host cell processes and in particular, redirect trafficking of the L. pneumophila phagosome and mediate its conversion into an ER-derived organelle competent for intracellular bacterial replication. L. pneumophila also manipulates host cell death and survival pathways in a way that allows continued intracellular replication.